Therapy with INTRON® A (Interferon alfa-2b, recombinant) for Injection is commonly associated with mild-to-moderate flu-like symptoms such as fever, muscle aches, joint pain, chills, and fatigue. These symptoms are typically most prominent at the start of therapy, and may lessen after the first few weeks.

Other frequently occurring side effects include loss of appetite, nausea and vomiting, dizziness, diarrhea, hair loss, irritability, depression, insomnia, and somnolence (sleepiness). As with other interferons, very infrequent reports of suicidal behavior (ideation, attempts, and completed suicides) have been associated with treatment.

However, some people have no side effects, and most others feel well enough to go to work and even travel during INTRON A therapy.

An approach to help patients manage side effects

Many patients can gain control of the side effects associated with INTRON® A therapy by referring to this A-through-F guide:

• Acetaminophen or ibuprofen can prevent or relieve fever and headache.
• Bedtime or early evening administration of INTRON® A therapy may allow you to sleep through the flu-like symptoms.
• Conserve your energy and get plenty of rest.
• Drink plenty of fluids before and during therapy.
• Eat balanced meals with an adequate number of calories.
• Focus on the positive!